By American Academy of Ophthalmology, Robert H. Rosa Jr. MD
Part four provides fabrics in elements: half I, Ophthalmic Pathology; and half II, Intraocular Tumors: medical facets. half I makes use of a hierarchy that strikes from basic to express to assist derive a differential analysis for a particular tissue. half II is a compilation of chosen medical facets of significance to the overall ophthalmologist. Following half II are the yankee Joint Committee on melanoma 2010 staging types for ocular and adnexal tumors.
Upon finishing touch of part four, readers can be capable to:
Describe a based method of figuring out significant ocular stipulations according to a hierarchical framework of topography, affliction strategy, basic analysis and differential diagnosis
Summarize the stairs in dealing with ocular specimens for pathologic examine, together with acquiring, dissecting, processing, and marking tissues
Identify these ophthalmic lesions that point out systemic sickness and are most likely lifestyles threatening
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Additional info for 2014-2015 Basic and Clinical Science Course (BCSC): Section 4: Ophthalmic Pathology and Intraocular Tumors
See BCSC Section 7, Orbit, Eyelids, and Lacrimal System, for further discussion. Any time a previous biopsy has been performed at the site of the present pathology, the sections of the previous biopsy should be requested and reviewed with the pathologist who will interpret the second biopsy. The surgical plan may be altered substantially if the initial biopsy was thought to represent, for example, a basal cell carcinoma when in fact the disease was a sebaceous carcinoma. In addition, the pathologist will be able to interpret intraoperative frozen sections more accurately when the case has been reviewed in advance.
A B C D E A, Epibulbar conjunctiva with regular, nonkeratinizing stratified squamous epithelium. B, Palpebral conjunctiva with epithelial ridges. Strama contains vessels and inflammatory cells (arrow). C, Conjunctiva at the fornix may contain pseudoglands of Henle, infoldings of conjunctiva with abundant goblet cells (arrows). D, Periodic acid-Schiff (PAS) stain highlights the mucin in goblet cells (arrow). E. Caruncular conjunctiva, containing sebaceous glands (5) and hair follicles (H) .
The immunohistochemical stains commonly used in ophthalmic pathology work because a primary antibody binds to a specific antigen in or on a cell, and because that antibody is linked to a chromogen, usually through a secondary antibody (Fig 4-1). The color product of the chromogens generally used in ophthalmic pathology is brown or red in tissue sections, depending on the chromogen selected for use (Fig 4-2). Red chromogen is especially helpful in working with ocular pigmented tissues and melanomas, because it differs from the brown melanin pigment (see Fig 4-7).
2014-2015 Basic and Clinical Science Course (BCSC): Section 4: Ophthalmic Pathology and Intraocular Tumors by American Academy of Ophthalmology, Robert H. Rosa Jr. MD