By Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein
In recent times the significance of antigen-presenting cells and their impression at the eyes has been elucidated. we've discovered that almost each constitution of the attention harbors those cells, but they fluctuate of their actions and therefore within the ways that they shield opposed to - or perform - illnesses of the attention. Antigen-Presenting Cells and the attention summarizes present wisdom approximately ACPs often, and their position within the eye, specifically.
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Extra info for Antigen-presenting cells and the eye
It is of note that the fluid-phase transport of antigens into the lymph node can occur only for small antigens (<80 kD) but not larger particles or whole bacteria. It is tempting to speculate whether resident Mphs within the inflamed tissue might phagocytose and process whole bacteria into smaller protein sized DC Migration for the Induction of Immunity 29 antigens that are then exocytosed and delivered within the fluid phase to the lymph node. This transport of small soluble antigens might also be relevant for antigen delivery to B cells, as some tracer molecules can reach T- as well as B-cell areas, thereby finally enabling Th cell-dependent B-cell responses.
Pathogen recognition will further induce migration and maturation of the MoDCs, which can then prime newly arriving naive T cells or perpetuate the stimulation of already primed but 30 Lutz not fully differentiated T cells as a third wave for small antigens or a second wave for larger antigens. MECHANISMS OF DC MIGRATION When peripheral tissues such as the skin are inflamed, infiltrated by microbes, or triggered by haptens, resident DCs start to emigrate via the afferent lymphatics to reach the draining lymph node (Fig.
Sonoda KH, Stein-Streilein J. CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance. Eur J Immunol 2002; 32:848–857. Nakamura T, Sonoda KH, Faunce DE, et al. CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune privileged site. J Immunol 2003; 171:1266–1271. Taylor A. A review of the influence of aqueous humor on immunity. Ocul Immunol Inflamm 2003; 11:231–241.
Antigen-presenting cells and the eye by Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein