By L. D. Bergelson (auth.), Gheorghe Benga, Joseph M. Tager (eds.)
Membrane examine holds a significant place in mobile and molecular biology. in recent times it has turn into transparent that the learn of membranes on the molecular point is of serious significance not just to decipher all mobile methods but in addition to appreciate the adjustments resulting in irregular cells (including melanoma cells) and/or to appreciate the motion of assorted medications. This publication covers the multidisciplinary method of study during this zone and the everlasting desire for info concerning fresh advances. it is going to serve either employees learning uncomplicated features of membrane constitution and serve as in addition to medically orientated scientists. the choice of issues illustrating interconnections among uncomplicated and utilized membrane biology will cross-fertilize learn in either groups.
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Extra resources for Biomembranes: Basic and Medical Research
1983 Lenaz et al. 1983b 29 3. Effects of Fluidity on Protein Dynamics A InV A~B~C 1/T B InV 1/T c InV 1/T Fig. 2. Possible reasons for breaks in Arrhenius plots (Lenaz 1986). A, Change in the rate-limiting step for two processes having different activation energies. B, Temperaturedependent conformational change. C, Phase change in the solvent structure. A property largely investigated in lipid-dependent enzymes is their anomalous temperature dependence. Most membrane enzymes exhibit breaks in Arrhenius plots with an increase of activation energy below the break (Raison 1972, Lenaz 1979).
5 ~. 4 Fig. 3. Continued. tion. For example, ATPase activity in submitochondrial particles or isolated membranous ATPase, exhibits a break around 18 ° - 24°C, while the thermotropic transition in mitochondrial lipids occurs at near O°C (Schneider et al. 1985). In reconstituted systems, however, the relation with phase transitions appears to hold better; for example, in dimyristoyl lecithin-reconstituted liposomes, the break in ATPase activity occurs at 25°C, whereas in dioleyllecithin-reconstituted liposomes the break disappears (Solaini et al.
Membrane Fluidity and Its Alterations in Disease Cooper RA (1980) Hemolytic syndromes and red cell membrane abnormalities in liver disease. Semin HematoI17:103-112 Corda D, Pasternak C, Shinitzky M (1982) Increase in lipid microviscosity of unilamellar vesicles upon creation of membrane potential. J Membr BioI 65:232-236 Cornell BA, Pope JM (1980) Low frequency and diffuse motion of aligned phospholipid multilayers studied by pulsed NMR. Chern Phys Lipids 27:151-164 Cronan JE Jr, Gelmann EP (1975) Physical properties of membrane lipids; biological relevance and regulation.
Biomembranes: Basic and Medical Research by L. D. Bergelson (auth.), Gheorghe Benga, Joseph M. Tager (eds.)