By M.J. Jager, L. Desjardins, T. Kivelä, B.E. Damato, F. Bandello
Uveal cancer is an competitive type of melanoma that could contain the iris, the ciliary physique, and/or the choroid, that is the most situation of this tumor. sufferers usually desire to learn approximately remedy offerings and the result of various methods. very important present scientific questions are no matter if a biopsy will be taken of choroidal melanomas, what could be performed with this biopsy, and even if high-risk sufferers might be screened usually. This quantity describes the medical features of uveal cancer besides the several present innovations on hand for therapy, similar to radioactive plaque remedy, proton beam treatment, and native tumor resection. moreover, thoughts for taking biopsies and characterizing biopsy fabric are tested. destiny treatments akin to anti-VEGF therapy and ideas for the therapy of metastases also are mentioned. citizens with an curiosity in ocular oncology, ophthalmologists or physicians facing uveal cancer, in addition to sufferers wishing to understand extra approximately this malignancy will discover a topical replace on uveal cancer during this booklet.
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Extra info for Current Concepts in Uveal Melanoma (Developments in Ophthalmology)
Arch Ophthalmol 2001;119:969–982. 30 Bergman L, Nilsson B, Lundell G, Lundell M, Seregard S: Ruthenium brachytherapy for uveal melanoma, 1979–2003: survival and functional outcomes in the Swedish population. Ophthalmology 2005;112:834–840. 31 Damato B, Patel I, Campbell IR, Mayles HM, Errington RD: Local tumor control after Ru-106 brachytherapy of choroidal melanoma. Int J Radiat Oncol Biol Phys 2005;63:385–391. 32 Kaiserman N, Kaiserman I, Hendler K, Frenkel S, Pe’er J: Ruthenium-106 plaque brachytherapy for thick posterior uveal melanomas.
A A choroidal melanoma in the right eye, close to the macular area. b The melanoma was treated successfully by positioning of the Ru-106 applicator eccentrically, in order to protect the fovea. 5 years after treatment. brachytherapy are compared to I-125 brachytherapy, treating tumors of similar size, a better preservation of visual acuity was observed in the Ru-106 patients [26, 35, 44, 51]. This can be explained by the fact that Ru-106 plaques emit beta rays, which have a more limited range than the I-125 gamma source, and thus provide a significantly lower dose to the lens, macula and optic nerve head .
14 Lommatzsch P, Klug H: Ultrastructural changes of the retina damaged by radiation. Ber Zusammerkunft Dtsch Ophthalmol Ges 1966;67:158–163. 15 Lommatzsch P: On the problem of radiation cataract in irradiation of the anterior eye segment. Klin Monbl Augenheilkd 1967;150:683–688. 16 Lommatzsch PK, Ballin RE, Helm W: Fluorescein angiography in the follow-up study of choroidal melanoma after 100Ru/106Rh plaque therapy. Retina 1987;7:148–155. 17 Lommatzsch PK, Albert W, Lommatzsch R, Rohrwacher F: Radiation effects on the optic nerve observed after brachytherapy of choroidal melanomas with 106Ru/106Rh plaques.
Current Concepts in Uveal Melanoma (Developments in Ophthalmology) by M.J. Jager, L. Desjardins, T. Kivelä, B.E. Damato, F. Bandello