Download e-book for iPad: Muller Cells in the Healthy and Diseased Retina by Andreas Reichenbach

By Andreas Reichenbach

ISBN-10: 1441916717

ISBN-13: 9781441916716

Müller cells make up simply 0.005% of the cells in our vital worried process. they don't belong to the extra esteemed relatives of neuronal cells yet to the glia, a kinfolk of cells that till lately have been noticeable as mere filling fabric among the neurons. Now, even if, all that has replaced. Sharing the insights of greater than 1 / 4 century of study into Müller cells, Drs. Andreas Reichenbach and Andreas Bringmann of Leipzig collage make a compelling case for the significant function Müller cells play.

Everyone has the same opinion that the attention is a truly specific and flexible experience organ, but it has grew to become out lately that Müller cells are atypical and multipotent glial cells. within the retina of so much vertebrates or even of many mammals, Müller cells are the single kind of (macro-) glial cells; therefore, they're accountable for a wealth of neuron-supportive services that, within the mind, rely on a department of labour between astrocytes, oligodendrocytes, and ependymal cells. Even past this sort of position within the imperative apprehensive process as "model glia", Müller cells are tailored to numerous intriguing roles in help of imaginative and prescient. They bring the sunshine stimuli to the photoreceptor cells within the inverted vertebrate retina, relief the processing of visible details, and are liable for the homeostatic upkeep of the retinal extracellular milieu.

In Müller Cells within the fit and Diseased Retina, aimed not only at neurobiologists yet at a person all in favour of retinal degeneration, each perspective of Müller cells is roofed, from an creation to their simple homes, via their roles as ‘light cables’ and ‘shock absorbers’, to the half they play in illnesses and issues of the attention. as soon as those have all been lined intimately, the authors movement directly to speak about the longer term path of study into those small yet effective mobile phenomena.

About the Authors

Dr. Andreas Reichenbach was once born in 1950 in Leipzig, Germany. He studied drugs and really expert as a physiologist, engaged on the mammalian retina. on the grounds that 1984, he has centred his efforts – and people of an increasing number of fellows in his workforce – on Müller phone learn. He has held a professorship at Leipzig college in view that 1994.

After learning biology, Dr. Andreas Bringmann (* 1960) labored within the box of systemic neurophysiology till he was once encouraged in 1996 via Andreas Reichenbach to investigate the main fascinating phone, the Müller mobilephone. he's now within the division of Ophthalmology of the collage of Leipzig the place he's the pinnacle of the fundamental study Laboratory.

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Additional resources for Muller Cells in the Healthy and Diseased Retina

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2 A The Vertebrate Retina as a Part of the CNS 27 B Fig. 14 The pecten oculi of the avian eye provides a peculiar additional glucose (and oxygen) supply of the inner retina via the vitreous body. a, b, The comb-like structure of the pecten oculi in a chicken eye is revealed by scanning electron microscopy. c, Transmission electron microscopy shows that the pecten oculi consists of a large number of blood vessels, covered by glia-like cells. 0 μm (c), respectively. , 1999 a basement membrane, and are ensheathed by glial cell processes.

There are three types of neurons that lie in series and mediate the forward transmission of the visual information from the photoreceptor outer segments (where light is absorbed by the photosensitive pigments) at the outer surface of the neural retina to the axons at the inner surface of the retina running towards the optic nerve: Photoreceptor cells (the first-order neurons of the retina), bipolar cells (the major second-order neurons), and ganglion cells (the third-order neurons). Photoreceptor 22 1 Introduction Fig.

As a result in most adult mammalian retinas (d), the combined choroidal and intraretinal glucose and oxygen supply allows for a sufficient oxidative (or, at least, mixed oxidative/glycolytic) energy metabolism of retinal neurons (and, perhaps dependent on the distance to blood vessels, also of many Müller cells). A transition from (b) to (c) may be enforced after cessation of the oxygen breathing of premature infants (VI). In such cases, the retina becomes hypoxic and responds by glial VEGF production and (pathogical) neovascularization.

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Muller Cells in the Healthy and Diseased Retina by Andreas Reichenbach


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